Very recently, leukemia inhibitory factor (LIF) was shown to belong to the IL-6 family of cytokines, similarly activating STAT-3, and was recently revealed as a super-enhancer-controlled regulator of CSC properties, confirming the role of STAT-3 transcription factor in the functional regulation of CSCs in osteosarcoma[91]. Here, STAT3 is linked to osteosarcoma.