JAK/STAT-5 activation belongs to the downstream signaling associated with various cytokine/hormone-induced signaling pathways, including prolactin, IL-2, IL-3, etc. Oct4 promoted osteosarcoma development by supporting the maintenance of CSCs through the increase in AK055347, a long-noncoding (lnc) RNA. The gene discussed is POU5F1; the disease is osteosarcoma.