Ewing sarcoma is associated with a fusion oncoprotein Ewing Sarcoma breakpoint region 1-Friend leukemia integration 1 transcription factor (EWS-FLI1) that has been shown to be associated with epigenetic modulation, specifically DNA methylation, as well as histone acetylation and deacetylation[49,50]. This evidence concerns the gene EWSR1 and Ewing sarcoma.