MYC and high grade B-cell lymphoma: More recently, a phase 2 study of oral CUDC-907 for the treatment of relapsed/refractory diffuse large and high-grade B-cell lymphoma (DLBCL and HGBL) patients with enhanced Myc-expression and/or altered MYC gene constitutions (e.g., altered gene composition by translocation) was published revealing an overall response rate of 22% in the MYC-altered disease patients[87].