It has been reported that MRD MM sub-clones could overexpress CD11a, CD11c, CD29, CD44, CD49d CD49e, CD54, CD138, CXCR4, and HLADR in the GEM2010MAS65 study involving 40 elderly patients[93] treated with nine cycles of VMP (bortezomib, melphalan, and prednisone) or alternating VMP to Rd (lenalidomide and dexamethasone). This evidence concerns the gene ICAM1 and Miyoshi myopathy.