A general role for GSK3B in sustaining resistance to chemotherapy has been validated also in other types of cancers and 9-ING-41, a novel GSK3B inhibitor developed by actuate therapeutics, is currently undergoing phase 1 and phase 2 trials, as a single agent and in combination with cytotoxic agents, in patients with refractory cancers, including CRCs[9]. This evidence concerns the gene GSK3B and cancer.