ATP7B and colorectal carcinoma: Accordingly, it has been reported that increased levels of ATP7B are associated with poor outcome in CRC patients receiving oxaliplatin-based chemotherapy[23], whereas a large meta-analysis of literatures and datasets performed by Sun et al. [24] revealed that high CTR1 level predicts prolonged survival and enhanced response to platinum-based regimens in cancer patients with a number of epithelial cancers.