However, dMMR/MSI-H CRCs also highly upregulate the expression of immune checkpoints - (i.e., PD-1 ligands, CTLA-4 ligand, LAG-3, and IDO1) that account for the suppression of an active immune response despite the high tumor infiltrating lymphocyte count [Figure 4][158]. The gene discussed is LAG3; the disease is neoplasm.