The first anti-angiogenic agent entering the clinic for the treatment of mCRC has been bevacizumab, a humanized monoclonal antibody anti-VEGF-A which binds circulating VEGF-A and blocks the interaction with its cell surface receptors (VEGFR1 and 2), thus reducing microvascular growth and inhibiting the blood supply to the tumor tissues[140]. Here, VEGFA is linked to neoplasm.