Because CD47 has roles independent of SIRPα, investigators have successfully used the blockade of CD47 to affect additional interactions, including opsonization of tumor cells for antibody-dependent cellular cytotoxicity (ADCC) by the Fc receptor for IgG (FcγR) on macrophages, neutrophils, and non-SIRPα expressing NK cells[17]. This evidence concerns the gene SIRPA and neoplasm.