Finally, a variety of pediatric solid tumor histologies, including Ewing sarcoma, medulloblastoma, atypical teratoid/rhabdoid tumor, primitive neuroectodermal tumor, pediatric high-grade glioma, and diffuse intrinsic pontine glioma were found to have diffuse CD47 expression; the brain tumors all showed response to CD47 blockade in xenograft models[39,40]. Here, CD47 is linked to pediatric high-grade glioma.