S100B and lung cancer: The role of Nef as a chemopreventive agent has been emphasized, it inhibits angiotensin II stimulated vascular smooth-muscle proliferation, induces reactive oxygen species (ROS)-dependent mitochondrial mediated apoptosis in liver and lung cancer cells, inhibits the proliferation of osteosarcoma cells and inhibits growth and migration of gastrointestinal stromal cells[27-31].