CD274 and non-small cell lung carcinoma: Although checkpoint inhibitors plus chemotherapy were found to be correlated with prolonged OS, compared with chemotherapy alone (HR = 0.74, P = 0.0002) in an analysis comprising 2978 NSCLC patients, significant heterogeneity was revealed between trials and according to the specific checkpoint inhibitor applied and the degree of PD-1/PD-L1 expression[51].