CD274 and non-small cell lung carcinoma: The approval of this type of chemotherapy - immunotherapy combination is based on the phase III KEYNOTE-189 trial which randomized 616 patients with advanced, PD-L1-unselected, non-squamous NSCLC in a 2:1 ratio to chemotherapy (cisplatin/carboplatin with pemetrexed) with or without pembrolizumab[3,15,16].