To date, some clinical trials are ongoing to better evaluate different combinations of ICIs and RT in pancreatic cancer; for example, a combination of nivolumab, ipilimumab and RT are used in the trials NCT03104439 and NCT02866383; and tremelimumab and/or MEDI4736 (anti-PD-L1) in combination with RT are used in the trials NCT02311361 and NCT02639026. This evidence concerns the gene CD274 and familial pancreatic carcinoma.