CD274 and familial pancreatic carcinoma: Nowadays, personalized neoantigen-based vaccines are being tested in phase I clinical trials with the purpose of assessing their safety and effectiveness in pancreatic cancer patients following surgical resection and adjuvant chemotherapy (NCT03122106; NCT03558945; NCT03956056), alone or combined with programmed cell death protein 1 ligand (PD-L1) inhibitors (NCT04161755).