The increased expression of TIM-3 (T-cell immunoglobulin and mucin domain 3), LAG-3 (lymphocyte activation gene 3), and BTLA (B and T lymphocyte attenuator) on CD8+ TILs are associated with adaptive resistance to anti-PD-1 in NSCLC[62-65]. The gene discussed is HAVCR2; the disease is non-small cell lung carcinoma.