Hypoxia induces the up-regulation of different genes involved in glucose metabolism, cell angiogenesis, cell proliferation, polarization of macrophages into Tumor Associated Macrophages, Treg recruitment and infiltration of myeloid derived suppressor cells leading to the inhibition of CD3+ T cells and the cytotoxic functions of CD8+ T cells[78,79]. This evidence concerns the gene CD8A and neoplasm.