In our study, we demonstrated the protective effect of dapagliflozin on LPS-induced endotoxic shock with AKI in streptozotocin-induced diabetic mice, based on the increased FITC-sinistrin GFR, decreased renal tubular injury score and KIM-1 IHC staining, and increased E-cadherin staining. This evidence concerns the gene CDH1 and acute kidney injury.