In our study, we demonstrated the protective effect of dapagliflozin on LPS-induced endotoxic shock with AKI in streptozotocin-induced diabetic mice, based on the increased FITC-sinistrin GFR, decreased renal tubular injury score and KIM-1 IHC staining, and increased E-cadherin staining. The gene discussed is HAVCR1; the disease is acute kidney injury.