GWAS studies have linked variants of patatin-like phospholipase domain-containing protein 3 (PNPLA3), transmembrane 6 superfamily 2 (TM6SF2), and MBOAT7 with all histological stages of Non-alcoholic fatty liver disease (NAFLD) 5, 6. The gene discussed is TM6SF2; the disease is metabolic dysfunction-associated steatotic liver disease.