And found that Natural killer cell mediated cytotoxicity, Th1, Th2, and Th17 cell differentiation, C-type lectin receptor signaling pathway, NOD-like receptor signaling pathway, MAPK signaling pathway, and some neurodegenerative disease pathway, for example, Huntington's disease and Alzheimer's disease, were enriched in the DECRs (Figure 3B, Supplemental Table S1). This evidence concerns the gene CLEC4D and Alzheimer disease.