Overexpression of Mfn2 triggered cervical tumor cell apoptosis via a mitochondrial-dependent pathway; repressed breast cancer cell proliferation, migration, and invasion by the inhibiting Ras-ERK1/2 signaling pathway; and inhibited urinary bladder carcinoma cell proliferation via inhibition of G1 to S phase transition[31,32]. This evidence concerns the gene MAPK3 and breast carcinoma.