BTK and B-cell chronic lymphocytic leukemia: While the development of novel targeted therapies and combining these therapies, such as BTK inhibitors, PI3K inhibitors, and BCL2 inhibitors, has significantly improved the long-term remission rates in lymphomas like CLL, a cure is sometimes still difficult to achieve due to the development of resistance clones, interruptions in treatment due to toxicities, or lack of adherence to treatment[127].