Likewise, Mabuchi et al. [114] showed that treatment with another allosteric inhibitor, everolimus (RAD001), enhanced cisplatin-induced apoptosis in platinum-resistant ovarian cancer cell lines (SKOV3 and OVCAR-10) with high AKT/mTOR activity, and inhibition of tumor growth and angiogenesis in mouse SKOV3 xenograft models. The gene discussed is AKT1; the disease is ovarian carcinoma.