A similar ATP-competitive AKT inhibitor afurosertib (GSK2110183) was investigated in a Phase Ib/II dose escalation study in combination with carboplatin and paclitaxel in a recurrent platinum-resistant ovarian cancer cohort, with positive findings of an ORR of 32% by Response evaluation criteria in solid tumors (RECIST) 1.1 and 52% by GCIC CA125 criteria, and a median progression-free survival of 7.1 months[74]. Here, AKT1 is linked to ovarian cancer.