Immunohistochemical staining of tissue microarrays (TMA) of different ovarian cancer subtypes showed significantly increased staining of p-4EBP1, p-p70S6K and p-S6, in particular p-4EBP1 expression correlated with high-grade tumors and poor prognosis[64]. The gene discussed is EIF4EBP1; the disease is ovarian carcinoma.