Buparlisib has also been tested in combination with other agents in a number of ovarian cancer trials, for example a Phase II trial was performed administering buparlisib in combination with the MEK1/2 inhibitor trametinib where ovarian cancer patients were shown to have a 29% overall response rate and median progression-free survival of seven months[87]. The gene discussed is MAP2K1; the disease is ovarian carcinoma.