There is evidence of epithelial CTCs expressing epithelial markers such as epithelial cell adhesion molecule (EpCAM); mesenchymal-like CTCs expressing traditional mesenchymal markers such as vimentin; CTCs co-expressing epithelial and mesenchymal markers; and CTCs expressing positive stem cells (CSC) markers such as CD4 and CD133 [which are called circulating tumor stem cells (CTSCs)][44]. The gene discussed is EPCAM; the disease is neoplasm.