On December 8, 2020 the FDA granted Breakthrough Therapy designation for its investigational K-RAS(G12C) inhibitor, sotorasib, for the treatment of patients with locally advanced or metastatic NSCLC with K-RAS(G12C) mutations, as determined by an FDA-approved test, following at least one prior systemic therapy. Here, KRAS is linked to non-small cell lung carcinoma.