MAP2K7 and Patent ductus arteriosus: Combining downstream MEK inhibition with hydroxychloroquine - an inhibitor of autophagy - displayed synergistic anti-proliferative effects against pancreatic ductal adenocarcinoma (PDA) cell lines and promoted striking regression of PDA xenografts from 2 patients with PDA which was superior to (standard of care) gemcitabine plus nab-paclitaxel chemotherapy.