The three RAS genes, Kirsten rat sarcoma viral oncogene homolog (K-RAS), neuroblastoma RAS viral (v-ras) oncogene homolog (N-RAS) and Harvey rat sarcoma viral oncogene homolog (H-RAS), are the most commonly mutated oncogenes in human cancer with approximately one-third of all cancers driven by these oncoproteins, including 40%-50% of colorectal cancer and over 90% of pancreatic cancers[3,4]. The gene discussed is HRAS; the disease is colorectal cancer.