Until this is possible, the authors demonstrated proof of principle that combined treatment of MEK inhibitor selumetinib (AZD6244) with a pan-RTK inhibitor sorafenib synergistically reduced tumour growth in a mouse model of TNBC; albeit this combination is unlikely to be clinically useful due to the extensive off-target profile of sorafenib, which also targets RAF kinases. The gene discussed is MAP2K7; the disease is neoplasm.