How the genomic landscape of a tumor is shaped by anti-tumor immunity has been explored using large-scale genomic data sets of tumor biopsies across different tumor types[27], defining some recurrently mutated genes that showed positive association with antitumor activity, including beta-2-microglobulin (β2M), HLA-A, -B and -C and Caspase 8. This evidence concerns the gene CASP8 and neoplasm.