LGALS3 and acute lymphoblastic leukemia: Consistent with these findings, Fei et al.[49] found that in vitro, patient-derived B-ALL cells harvested from underneath a BMSC feeder cell layer, where they maintained direct cell-cell contact with feeder cells, had more galectin-3 on their cell surface relative to cells found in suspension above the cell layer or cells cultured in the absence of BMSCs.