LGALS3 and acute lymphoblastic leukemia: Hu et al.[50] similarly demonstrated that co-culture of ALL cells with BMSCs resulted in increased cell surface galectin-3 and chemoresistance, and extended this finding to demonstrate that transcriptional targets of the Wnt/β-catenin signaling pathway, previously implicated in chemoresistance, were upregulated in wild-type ALL cells co-cultured with BMSCs but not in galectin-3 knockout cells, suggesting that activation of this pathway is galectin-3-dependent[51].