G6PD and cancer: We have demonstrated that failed “kill switches” can still be triggered to fire in some canine tumors, and have proposed a collaboration with NCI to expand those studies in canine cancer to include the strategies discussed above, employing fluasterone sulfate for STS-expressing canine tumors, and with FDG to exploit the “kill switch” kinetics of irreversible uncompetitive inhibition of G6PD in canine tumors that avidly take up FDG.