NSCLC cells have previously been demonstrated to be susceptible to increased vinorelbine sensitisation by curcumin addition; cells were sensitised to vinorelbine-induced apoptosis by modulation of components of the mitochondrial pathway including BCL2, Bax, Bcl-xs, and Bcl-X, thereby releasing apoptogenic cytochrome c[46]. The gene discussed is BAX; the disease is non-small cell lung carcinoma.