BCL2 and B-cell chronic lymphocytic leukemia: Exogenous upregulation of miR-15/16 was shown to reverse the multidrug resistance of a gastric cancer cell line to a panel of anticancer drugs via direct regulation of the anti-apoptotic BCL2 protein[10] and to induce the intrinsic apoptosis pathway via negative regulation of BCL2 expression in CLL[27].