For example, expression of miR-16 was found to be downregulated in paclitaxel-resistant breast cancer cell lines, and exogenous overexpression of miR-16 sensitised breast cancer cells to Paclitaxel induced apoptosis and cytotoxicity via direct modulation of IκB kinase β (IKBKB)[14]. The gene discussed is IKBKB; the disease is breast cancer.