CXCL8 and colorectal carcinoma: In addition to the well-established role in angiogenesis, one of most accredited functions of IL-8 is to affect stemness properties through the induction of Snail-mediated EMT process: Hwang et al. [62] demonstrated that Snail-IL-8 axis regulates the stemness properties of the CD44+ subpopulation in CRC.