Several types of cells (i.e., macrophages, MSC, endothelial, epithelial and cancer cells) release IL-8 in TME: due the presence of its receptors, even in cells other than those which released IL-8, this chemokine is involved in promoting many features of cancer development, such as EMT, angiogenesis, tumor growth, metastasis and immunosuppressive microenvironment[59]. This evidence concerns the gene CXCL8 and neoplasm.