This finding was replicated in another study comparing two HPV-positive with two HPV-negative HNSCC cell lines, where the HPV-positive HNSCC cell lines demonstrated delayed resolution of γH2AX and 53BP1 foci and delayed repair of radiation-induced DSBs post-irradiation revealed through the neutral comet assay[25]. Here, TP53BP1 is linked to head and neck squamous cell carcinoma.