Strikingly, transcriptional analysis showed that pretreatment tumor biopsy samples from patients who turned out to be durable responders to the combination treatment displayed significant upregulation of EMT and myeloid activation gene expression signatures including AXL and TGFB1. In contrast, a negative regulation of EMT gene signature was downregulated; notably, PD-L1 and INFG levels were not associated with response. This evidence concerns the gene CD274 and neoplasm.