Although not initially developed as AXL-targeting agents, pan-TKIs that inhibit a spectrum of RTKs including AXL, most notably cabozantinib and sitravatinib, have shown promising activity in combination with ICB particularly in ICB-naïve renal cell carcinoma (NCT03937219, NCT03680521). The gene discussed is AXL; the disease is hereditary clear cell renal cell carcinoma.