CTLA4 and neoplasm: Data from The Cancer Genome Atlas (TCGA), PROSPECT, and BATTLE-1 showed that inflammatory changes in the tumor microenvironment were strongly associated with induction of EMT signatures in lung adenocarcinoma, which in turn correlated with upregulation of multiple suppressive immune checkpoint receptors or their ligands, including B7-H3, CTLA-4, PD-1, PD-L1, PD-L2, B and T lymphocyte attenuator, and T cell immunoglobulin and mucin-domain containing-3 (TIM-3)[45].