CD274 and non-small cell lung carcinoma: Notable among these is the trial in second-line advanced NSCLC (unselected for PD-L1 expression level), which has shown durable responses and encouraging long-term survival while maintaining a manageable safety profile over a two-year follow-up period, prompting a randomized phase III clinical trial vs. pembrolizumab in first-line PD-L1-high NSCLC (NCT03631706)[156].