NFKB1 and glioblastoma: Studies with GBM stem-like cells referred to as tumourspheres showed that inhibiting endogenous NF-κB activity either via selective antagonist of inhibitors of the κB (IκB) kinase (IKK) complex (IKKβ) or siRNA knockdown, which are involved in playing key roles in the activation of the canonical pathway of NF-κB, resulted in decreased tumorspheres formation[60].