In gemcitabine-resistant pancreatic cancer cells (MiaPaCa-2), DIM upregulated the expression of E-cadherin and suppressed zinc finger E-box binding homeobox 1 (ZEB1), vimentin, and slug, leading to a reversal of epithelial-to-mesenchymal transition[35]. This evidence concerns the gene ZEB1 and familial pancreatic carcinoma.