BBC3 and familial pancreatic carcinoma: The oncomir miR-221 was suppressed by DIM in pancreatic cancer cells (MiaPaCa-2), and the upregulation of miR-221 targets such as phosphatase and tensin homolog deleted on chromosome (PTEN), p53 upregulated modulator of apoptosis (PUMA), and the cyclin-dependent kinase (CDK) inhibitors p27 and p57 was observed[38].