To analyze if RHOV participated in the exosomal circ_0000519-modulated NSCLC development, H2170 and A549 cells were transfected with pcDNA3.1 or pcDNA3.1-RHOV, and then, the transfected or non-transfected cells were incubated with the exosomes from si-NC or si-circ_0000519-transfected H1299 cells (named as si-NC-exo or si-circ_0000519-exo). The gene discussed is RHOV; the disease is non-small cell lung carcinoma.