PDCD4 and myxoid liposarcoma: The difference in miRNA expression between trabectedin-sensitive and trabectedin-resistant myxoid liposarcoma cells (402-91 sensitive and 402-91/ET trabectedin-resistant cells) was investigated and the resistant cells showed two-fold higher miR-21 expression (target: PDCD4/programmed cell death 4) as well as three-fold lower let-7e expression (targets: CCND1, E2F5, SEMA4C)[132].