They demonstrated that exosomes transferred from fibroblasts to BC cells released their RNA and transposable elements into the target BC cells, thus resulting in the stimulation of the pattern recognition receptor retinoic acid-inducible gene I (RIG-I)[32] with subsequent activation of the signal transducer and activator of transcription 1 dependent antiviral signaling pathway[33]. This evidence concerns the gene STAT1 and breast cancer.