ALDH1A1 and lung adenocarcinoma: Recently, an ALDH1A1-induced resistance has also been found against tyrosine kinase inhibitors in in vitro and in vivo models of lung adenocarcinoma through the upregulation of superoxide dismutase and glutathione peroxidase 4 as well as ALDH1A1 itself, key enzymes involved in the redox signaling[93].