The in vivo study, orthotopically implanted patient-derived glioblastoma NS-derived tumors that co-express Pgp and CAXII into BALB/c nu/nu mice, resensitized drug resistant glioblastoma to temozolomide and showed a significant improvement in overall survival that was related to the CA XII mechanism of action to indirectly reduce Pgp activity in drug resistant cells[45]. The gene discussed is CA12; the disease is glioblastoma.