In vivo antitumor activity determined through intra-peritoneal administration of curcumin in a dose of 45 mg/kg against xenografted 801D highly metastatic human lung cancer, showed greater size reduction in curcumin-treated animals with very clear and intact tumor boundary, which is indicative of significantly decreased tumor invasiveness and the observations were supported by decrease in MMP-2 and MMP-9 expressions[161]. This evidence concerns the gene MMP9 and neoplasm.