The BALB/c nude mice xenograft model of human colorectal carcinoma cells HCT116, where HCT116 cells were separately transfected with pre-mRNA processing factor 4B (PRP4) and pre-mRNA processing factor 8 (PRP8), on treatment with intraperitoneally-injected 50 mg/kg of curcumin showed that the overexpressed PRP8 could not resist the curcumin-induced apoptosis as evident from tumor size and Western blot analysis showing overexpressed PRP8. The gene discussed is PRP4K; the disease is colorectal carcinoma.