PKD1 and neoplasm: Silencing of expression of protein kinase D1 (PKD1) by using relevant SiRNA pretreatment before the curcumin dose showed substantially decreased levels of PKD1 expressions as well as lower levels of β-catenin on the cell surface[172], which points towards probable role of PKD1 in overexpression of β-catenin and curcumin mediated inhibition of tumor growth.