Human Breast cancer BT-474 cells with overexpression of HER-2, xenografted in athymic nude mice showed promising results with decreased mean tumor size as compared to other groups on treatment with 45 mg/kg dose of curcumin twice/week in combination with herceptin (2 mg/kg) once a week on intraperitoneal injection for four weeks[133]. This evidence concerns the gene ERBB2 and breast cancer.