Another xenograft model of A549 on treatment with 20 mg/kg subcutaneous dose of lipid-polymer hybrid nanoformulation-encapsulating curcumin for seven weeks, decreased the tumor volume by 52.1% and substantial decrease in Annexin A2 as compared to the control group, whereas the group treated with liposomal curcumin showed 32.2% decrease in tumor volume[169]. Here, ANXA2 is linked to neoplasm.