Similar effects were observed with GLI inhibitor, Gant61, indicating regulation of ABCB1 by HH/GLI signaling, Interestingly, cyclopamine did not increase chemosensitivity in several further cancer cell lines, including ACHN renal cancer, Jurkat T-lymphocytes, and PC3 prostate cancer cells, suggesting that either these cells do not have active HH/GLI signaling or chemoresistance is governed by other transcription factors[160]. The gene discussed is GLI1; the disease is Familial prostate cancer.