Known non-canonical Notch targets include YY-1[137], NF-κB[138,139], β-catenin[140], and HIF1α[141], all of which are well-evidenced regulators of the ABCB1 gene, but data are lacking for their regulation by Notch signaling in chemoresistant cancer associated with ABCB1. Here, ABCB1 is linked to cancer.