The molecular identification of the reactivated PITX2 transcriptional complex in cancer is currently unknown; however, it appears that PITX2 requires additional co-factors or interaction partners to transcriptionally regulate its target genes[330-332], as commonly seen in developmental PITX2 signaling with, for example, SOX2 (sex determining region Y-box 2) and LEF1[333] or FOXC1 (Forkhead box C1)[334]. Here, PITX2 is linked to cancer.