In a study performed on breast cancer cells, binding of hyaluronan to the CSC marker, CD44+, a target gene of Wnt signaling[223], upregulated HAT CBP/p300, thus promoting acetylation of β-catenin and the inflammatory transcription factor, NF-κB-p65, leading to activation of TCF/LEF and NF-κB-specific transcription. Here, NFKB1 is linked to breast carcinoma.