Next, to ensure that the DUPA-FRET conjugate would be selectively internalized by PSMA-mediated endocytosis, the conjugate was incubated for 1 hour with either a PSMA-negative (PC-3 cells) or PSMA-positive (LNCaP cells) prostate cancer cell line[22]. The gene discussed is FOLH1; the disease is Familial prostate cancer.