mCRPC cell lines- Reduction of AR/AR-Vs proteins via inhibition of mTOR pathway- Reduction of proliferation- Induction of apoptosis- Reduction of p-mTOR, p-Akt, p-S6RPmCRPC xenografts- Reduction of xenograft tumor growth- Reduction of proliferative rate- Increase of apoptotic rate. The gene discussed is MTOR; the disease is neoplasm.