HMGCR and posterior cortical atrophy: Close scrutiny of publicly available human datasets has confirmed the significant increase in the expression of multiple genes involved in FA synthesis [i.e., ATP citrate lyase (ACLY), acetyl-CoA carboxylase and FASN], FA desaturation [i.e., stearoyl-CoA desaturase 1], FA elongation [i.e., very-long chain FA elongases (ELOVL5, 7)], FAO [i.e., carnitine palmitoyltransferase 1 (CPT1) and ECl2], and cholesterol synthesis [i.e., 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)] in PCa compared to nonmalignant tissue, especially in the metastatic setting[22].