AR and neoplasm: Androgen sensitive andmCRPC cell lines- Reduction of AR/AR-V7 proteins- Reduction of proliferation/soft agar colony growth- Cell cycle inhibition- Induction of apoptosis- Induction of endoplasmic reticulum (ER) stress- Reduction of protein synthesismCRPC xenografts- Reduction of xenograft tumor growthHuman mCRPC organoids- Reduction of mCRPC organoid growth