Therefore, we assessed DNMT (1, 3a, and 3b) and TET (1, 2, and 3) expression in leukocytes as well as their activity in extracellular vesicles (EVs), submicron intact vesicles (Blair et al., 2016), isolated from plasma collected from scleroderma (scl) and idiopathic (i) PAH patients. The gene discussed is DNMT1; the disease is pulmonary arterial hypertension.