Patient 1 is a 74 year-old male with a history of coronary artery disease, inferior myocardial infarction status-post stent placements, aortic valve stenosis, bilateral cataracts, bilateral ocular hypertension, and prostate cancer (PCa), pT3b, Gleason 9 (4 + 5) with pre-treatment prostate-specific antigen (PSA) 14.2 ng/mL. Here, KLK3 is linked to stricture.