After infection with entero-invasive bacterium Shigella flexneri in Shigelosis, the host intestinal epithelial cells (IECs) show activation of NF-κB with IL-8 induction which propagates from the infected to uninfected adjacent cells and generates rapid amplification of IL-8 production by uninfected bystander cells [60]. Here, CXCL8 is linked to infection.