Driver mutations have been found in several RNA-binding proteins (e.g., SF3B1, U2AF1, SRSF2, HNRNPA2B1, SRRM2) in cancers ranging from blood malignancies to glioblastoma [37–39], but several questions remain regarding how widely this group of proteins and their targets are involved in cancer. Here, SRSF2 is linked to cancer.