Driver mutations have been found in several RNA-binding proteins (e.g., SF3B1, U2AF1, SRSF2, HNRNPA2B1, SRRM2) in cancers ranging from blood malignancies to glioblastoma [37–39], but several questions remain regarding how widely this group of proteins and their targets are involved in cancer. The gene discussed is U2AF1; the disease is cancer.