EZH2 and cancer: Based on previous studies, NEAT1 controls the initiation and progression of cancer by three molecular mechanisms: (i) influencing the expression level of downstream factors of EZH2, by acting as a scaffold RNA molecule for EZH2, (ii) playing crucial role as a miRNA sponge to disrupt the connections of several tumor suppressor miRNAs with their target mRNAs, and (iii) suppressing the expression of miR-129 (promotion of DNA methylation in the promoter region of miR-129) [7].