Interestingly, differences in somatic mutations have also been observed in various etiologies of HCC, with the TP53 mutations being linked to viral and alcohol etiologies of HCC [69] (similar to the patient composition of the TCGA and LCI cohorts), while ACVR2A (activin A receptor type 2A) mutations have been more commonly found in NASH-HCC [69]. This evidence concerns the gene TP53 and hepatocellular carcinoma.