RB1 and neoplasm: Among these, mutations in TP53 (Wilcoxon adjusted p = 7.58 × 10−9) and in RB1 (Wilcoxon adjusted p = 9.45 × 10−3) led to a significant increase in the estimated proportions of the Prol tumor cell-type (Fig. 4a and Additional file 1: Fig. S9).