According to previous studies, high expression of SYNJ2 was correlated with hepatocellular tumorigenesis via the CTCF/POLR2A-SYNJ2 axis [32] and with metastasis of glioma [13] and breast cancer through regulating the formation of lamellipodia and invadopodia [14]. The gene discussed is POLR2A; the disease is central nervous system cancer.