By analyzing 9781 samples, compared to normal tissues, SYNJ2 was upregulated in cholangiocarcinoma (CHOL), colon adenocarcinoma (COAD), liver hepatocellular carcinoma (LIHC), lung adenocarcinoma (LUAD), LUSC, prostate adenocarcinoma (PRAD), and stomach adenocarcinoma (STAD) and downregulated in glioblastoma multiforme (GBM), kidney chromophobe (KICH), kidney renal clear cell carcinoma (KIRC), and kidney renal papillary cell carcinoma (KIRP) (p < 0.05; Fig. 5B). The gene discussed is SYNJ2; the disease is cholangiocarcinoma.