However, based on the results of our study, SYNJ2 likely participated in the immune response by affecting filtration levels of immune cells, the mechanisms of which were complex with the fact that: (1) The infiltration levels of several antigen presenting cells (e.g., activated dendritic cells and neutrophils [33–37]), were significantly increased in LUSC samples with higher expression levels of SYNJ2. (2) SYNJ2 was positively associated with both infiltration levels of innate and acquired immune cells and expression levels of immune checkpoints in some cancers such as KICH and LIHC. This evidence concerns the gene SYNJ2 and cancer.