YAP1 and cancer: Similar results were observed in some other studies, which found that TEAD4 could promote EMT in cancer cells, such as glioma, head neck squamous cell carcinoma, colorectal cancer, etc [16, 37–39]. In our previous study, we found that metformin could inhibit the proliferation of BLCA cells by regulating the YAP1/TEAD4 complex [40]. Now, we systematically analyzed the potential biological function of TEAD4 in bladder cancer and found that TEAD4 was highly expressed in BLCA and negatively correlated with OS in BLCA patients.