AKT1 and bladder transitional cell carcinoma: In a similarily way, many molecues sponsored migration, invasion and EMT of BLCA cells in-vitro and in vivo through PI3K/AKT pathway, such as CERCAM [27]  and GAS6 [28].  On the contrary, some other molecules such as TSPAN7 [29] and ID2 [30] inhibited the cell migration and invasion via PI3K/AKT.