In addition, miRNA-326 [102, 103], miR-361-3p [104], miR-338-3p [105, 106], miR-182-5p [107], miR-1271 [108], miR-506-3p [109], miR-873-5p [110], miR-324-3p [111], miR-218 [112], miR-636 [113], miR-506 [114], miR-7-5p [115, 116], miR-124 [117], miR-150 [118], miR-202-3p [119], miR-144-3p [120] and miR-141-3p [121] also act as cancer suppressors and interact with critical Hh signaling regulators (such as Ptch, Smo and Gli1) to regulate tumor progression. The gene discussed is GLI1; the disease is cancer.