A recent investigation unveils that circGli1 interacts with p70S6K2 protein, which can block the binding of GSK3β with Gli1 and β-catenin, to facilitate Gli1 and β-catenin protein expression, activate hedgehog/Gli1 and Wnt/β-catenin pathways and further drive Cyr61 expression by boosting their downstream gene MYC expression, leading to accelerated cell migration and angiogenesis in melanoma. The gene discussed is GLI1; the disease is melanoma.