Moreover, MTHFD2 expression was strongly correlated with T stage (T1&2 vs. T3&4, p <  0.001; Fig. 2A), M stage (M0 vs. M1, p = 0.03; Fig. 2C), histologic grade (low grad vs. high grade, p <  0.001; Fig. 2D), pathologic stage (stage I-II vs. stage III-IV, p <  0.001; Fig. 2E), tumor subtype (papillary vs. non-papillary, p <  0.001; Fig. 2F), and human race (p <  0.001; Fig. 2G). This evidence concerns the gene MTHFD2 and neoplasm.