HTRA1 and bladder transitional cell carcinoma: Plenty of researches have reported some prognostic biomarkers for BLCA, including protein biomarkers, genomic biomarkers, epigenetic biomarkers, and transcriptomic biomarkers, such as fibroblast growth factor receptor 3 (FGFR3), Telomerase reverse transcriptase (TERT) mutation, One cut domain family member 2 (ONECUT2), polymerase (RNA) III (DNA directed) polypeptide G (POLR3G), Cyclin A1 (CCNA1), B cell lymphoma 2 (BCL2), Eomesodermin (EOMES), Vimentin (VIM), and high-temperature requirement A serine peptidase 1 (HtrA1) [27, 28] .