In support of the connection between Notch and PAX8 signaling, we found that other genes positively regulated by NOTCH3 (> four-fold increase upon NOTCH3 overexpression), including NGLDC, SNTB1, and ITGB3, belonged to a the 29-gene PAX8 signature that was reduced upon PAX8 knockdown in multiple human ovarian cancer cell lines [37]. The gene discussed is ITGB3; the disease is ovarian cancer.