MAPT and early-onset autosomal dominant Alzheimer disease: According to NIA/AA consensus guidelines [18], tissue sections confirmed the presence of Alzheimer disease neuropathologic changes: Aβ plaques were observed in neocortex and hippocampus but not in the striatum (Thal Phase 2); NFTs were observed in sections of association neocortex (Braak stage V); and sparse neocortical NPs were observed on Tau immunostained sections (CERAD score 1).